| BASEC ID | Project title | Type of project | Type of clinical trial | Study phase (clinical trials only) | multi- / monocentric | Category | Principal investigator | Sponsor | Investigational sites | Lead EC | Local EC(s) | Approval date | Minors | Study Ended | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2022-02137 | Subtypes of Modic type 2 changes and their association with low back pain | personal data/biological material | monocentric | Prof. Dr. med. Mazda Farshad | Universitätsklinik Balgrist |
Universitätsklinik Balgrist, Zürich |
Kantonale Ethikkommission Zürich | 06.01.2023 | |||||||
| 2022-02136 | M23-696: A Phase 3b/4 Randomized, Open-label, Efficacy Assessor Blinded Study, Comparing the Safety and Assessor Blinded Efficacy of Upadacitinib to Dupilumab in Subjects with Moderate to Severe Atopi More ... | clinical trial | drugs | phase 3 | multicentric | C | Dr. Ieva Saulite | AbbVie Inc. |
Kantonsspital St. Gallen, St. Gallen Inselspital, Universitätsklinik für Dermatologie, Bern Universitätsspital Basel, Dermatologie, Basel Universitätsspital Zürich, Dermatologische Klinik, Zürich |
Ethikkommission Ostschweiz (EKOS) | Ethikkommission Nordwest- und Zentralschweiz EKNZ, Kantonale Ethikkommission Bern, Kantonale Ethikkommission Zürich | 09.03.2023 | yes | ||
| 2022-02134 |
Risk factors for the use of a primary higher-constrained total knee arthroplasty – a retrospective single-center analysis |
personal data/biological material | monocentric | Prof. Dr. med. Sandro Fucentese | Universitätsklinik Balgrist |
Universitätsklinik Balgrist, Zürich |
Kantonale Ethikkommission Zürich | 22.12.2022 | |||||||
| 2022-02133 | Benefit-to-risk balance of coronary angiography in the critically ill | personal data/biological material | monocentric | Dr Hamid Merdji | Basel University Hospital |
University Hospital Basel, Basel |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | 10.02.2023 | |||||||
| 2022-02132 | Monocentric retrospective study of 341 children with Appendectomy: How frequent is oxyuriasis? | personal data/biological material | monocentric | Prof. med. Henrik Köhler | Kinderspital am Kantonsspital Aarau |
Kantonsspital Aarau, Aarau |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | 03.03.2023 | |||||||
| 2022-02131 | 19767_A multicenter, international, randomized, active comparator-controlled, double-blind, doubledummy, parallel-group, 2-arm, Phase 3 study to compare the efficacy and safety of the oral FXIa inhibi More ... | clinical trial | drugs | phase 3 | multicentric | C | Prof. Dr. med. Angelo Auricchio | Bayer AG |
Istituto Cardiocentro Ticino, Lugano lnselspital Bern, Bern Universitätsspital Basel, Basel Kantonspital Aarau AG, Aarau Kantonsspital Baden AG, Baden Kantonsspital St. Gallen, St. Gallen HFR Hôpital More ... |
Comitato etico cantonale Ticino | Ethikkommission Nordwest- und Zentralschweiz EKNZ, Ethikkommission Ostschweiz (EKOS), Kantonale Ethikkommission Bern, Kantonale Ethikkommission Zürich, Commission cantonale d'Éthique de la Recherche s More ... | 13.02.2023 | Study has ended | ||
| 2022-02130 | CAIN457C22301 - A randomized, parallel-group, double-blind, placebo-controlled, multicenter Phase III trial to evaluate efficacy and safety of secukinumab administered subcutaneously versus placebo, i More ... | clinical trial | drugs | phase 3 | multicentric | C | Prof. Dr. med. Andrea Rubbert-Roth | Novartis Pharma Schweiz AG |
Kantonsspital St. Gallen, St. Gallen Universitätsspital, Basel HFR Fribourg – Hôpital Cantonal, Fribourg |
Ethikkommission Ostschweiz (EKOS) | Ethikkommission Nordwest- und Zentralschweiz EKNZ, Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD) | 16.02.2023 | |||
| 2022-02129 | A two-part, randomized, placebo controlled, double blind, multicenter, Phase 3 study to evaluate the efficacy and safety of linerixibat for the treatment of cholestatic pruritus in participants with p More ... | clinical trial | drugs | phase 3 | monocentric | C | PD Dr. med. Benedetta Terziroli Beretta-Piccoli | GlaxoSmithKline Research & Development Limited |
Epatocentro Ticino, Lugano |
Comitato etico cantonale Ticino | 27.02.2023 | Study has ended | |||
| 2022-02128 | Post Intensive Care Syndrome in Swiss Pediatric survivors and their Families [PICSS-PF]: A Multi-center Longitudinal Observational Study | non clinical, involving persons | multicentric | A | Dr. Zahra Rahmaty | IUFRS/University Hospital of Lausanne |
IUFRS, CHUV, Lausanne Universitätsklinik für Kinderheilkunde, Bern Kinderspital - Luzerner Kantonsspital, Luzern Universitätskinderklinik beider Basel (UKBB), Basel Hôpitaux Universitaires de Genève ( More ... |
Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD) | Ethikkommission Nordwest- und Zentralschweiz EKNZ, Ethikkommission Ostschweiz (EKOS), Kantonale Ethikkommission Bern, Kantonale Ethikkommission Zürich, Commission cantonale d'Éthique de la Recherche s More ... | 25.04.2023 | yes | ||||
| 2022-02127 | An exploratory study on autoantibodies in cancer patients – IOSI-IRB-001 study | personal data/biological material | monocentric | Dr. med. Ilaria Colombo | Istituto Oncologico della Svizzera Italiana |
Istituto Oncologico della Svizzera Italiana, Bellinzona |
Comitato etico cantonale Ticino | 25.01.2023 | |||||||
| 2022-02126 | An Open-label, Dose Escalation, Phase 1/2 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-676 as a Single Agent and in Combination With Pembrolizumab in Adult More ... | clinical trial | drugs | phase 1 | multicentric | C | Prof. Dr. med. Martin Berger | Takeda Development Center Americas, Inc. (TDC Americas) |
Universitätsklinik für Medizinische Onkologie, Inselspital, Bern Hôpitaux Universitaires de Genève, Geneva Kantonsspital St.Gallen, Klinik für med. Onkologie & Hämatologie, St.Gallen Centre Hospitalie More ... |
Kantonale Ethikkommission Bern | Ethikkommission Ostschweiz (EKOS), Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD), Commission Cantonale d'éthique de la recherche Genève (CCER) | 13.07.2023 | |||
| 2022-02125 | Intraoperative neurophysiological markers to predict outcome in hemifacial spasm | personal data/biological material | monocentric | Prof. Dr. Med. Kathleen Seidel | Department of Neurosurgery, Inselspital |
Department of Neurosurgery, University Hospital Bern, Inselspital, Bern |
Kantonale Ethikkommission Bern | 06.04.2023 | Study has ended | ||||||
| 2022-02124 | Sleep disordered breathing in children and adolescents with obesity | non clinical, involving persons | monocentric | A | Dre Virginie Bayon | CHUV - CIRS - BH 06 |
CHUV, Lausanne |
Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD) | 26.01.2023 | yes | |||||
| 2022-02123 | Cancer du sein et CAFs (cancer associated fibroblasts) : identification de marqueurs de surface prédictifs de la réponse à la chimiothérapie néoadjuvante | personal data/biological material | monocentric | Dr Loïc Lelièvre | Fondation pour le perfectionnement et la recherche en gynécologie et obstétrique |
CHUV/UNIL, Lausanne |
Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD) | 23.03.2023 | |||||||
| 2022-02122 | Harnessing neoantigen reactive CD4+ T cells for adoptive T cell therapy in melanoma | non clinical, involving persons | monocentric | A | Dr Assma BEN AISSA | HUG |
HUG, geneva |
Commission Cantonale d'éthique de la recherche Genève (CCER) | 22.04.2024 | ||||||
| 2022-02121 | Bleeding of unknown cause, insight into a multifactorial bleeding disorder: a Swiss case-control study | non clinical, involving persons | multicentric | A | Dr Alessandro Casini |
University Hospitals of Geneva, Geneva Inselspital, Bern Centre for Laboratory Medicine, St Gallen Ente Ospedaliero Cantonale, Bellinzona Clinica Moncucco, Lugano Centre Hospitalier Universitaire Vaud More ... |
Commission Cantonale d'éthique de la recherche Genève (CCER) | Ethikkommission Ostschweiz (EKOS), Kantonale Ethikkommission Bern, Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD), Comitato etico cantonale Ticino | 01.02.2023 | ||||||
| 2022-02120 | Effect of heated saline in duration of cervical ripening in women having labor induction with cervical balloon: a randomized controlled study | clinical trial | other clinical trials | monocentric | A | Dr. Valeria LOMBARDI FÄH | Hôpitaux Universitaires de Genève |
Hôpitaux Universitaires de Genève, Genève |
Commission Cantonale d'éthique de la recherche Genève (CCER) | 17.04.2023 | |||||
| 2022-02119 | Mechanisms of type 1 diabetes endophenotypes, by cluster analysis | non clinical, involving persons | monocentric | A | Prof. Valérie Schwitzgebel | Hôpitaux Universitaire de Genève |
HUG, Geneva |
Commission Cantonale d'éthique de la recherche Genève (CCER) | 17.01.2023 | yes | |||||
| 2022-02118 | Optimized post mortem, multi-scale imaging and transcriptomic analysis of the human thalamus and cortex | deceased persons | monocentric | Prof. Andras Jakab | University of Zürich |
University Children's Hospital Zürich / University of Zürich, Zürich |
Kantonale Ethikkommission Zürich | 27.01.2023 | |||||||
| 2022-02116 | Introduction of a documentation protocol for Rezum water therapy of the prostate and analysis of practice patterns via retrospective application in a multiuser high-volume center. | personal data/biological material | monocentric | Prof. Dr. Christian Wetterauer | University Hospital Basel |
University Hospital Basel, Basel |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | 04.01.2023 | |||||||