| BASEC ID | Project title | Type of project | Type of clinical trial | Study phase (clinical trials only) | multi- / monocentric | Category | Principal investigator | Sponsor | Investigational sites | Lead EC | Local EC(s) | Approval date | Minors | Study Ended | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-D0086 | A Phase 3, Randomized, Double-blind, Add-on Study Evaluating the Safety and Efficacy of Navtemadlin Plus Ruxolitinib vs Placebo Plus Ruxolitinib in Patients with Myelofibrosis Who Have a Suboptimal Re More ... | clinical trial | in vitro diagnostic medical devices CDx | multicentric | C2 | Dr. med. Thomas Lehmann | Kartos Therapeutics, Inc. |
Cantonal Hospital Saint Gallen, St. Gallen Inselspital, University Hospital Bern, Bern University Hospital Basel, Klinik für Hämatologie Petersgraben 4 Ente Ospedaliero Cantonale, Institute for Oncol More ... |
Ethikkommission Ostschweiz (EKOS) | Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD), Kantonale Ethikkommission Bern, Kantonale Ethikkommission Zürich, Ethikkommission Nordwest- und Zentralschweiz EKNZ, Com More ... | 16.10.2025 | ||||
| 2025-D0077 |
Clinical Safety and effectiveness of Straumann Dynamic Navigation System (Falcon): A prospective multicenter and multinational Clinical Investigation CR 2023_02 Straumann Falcon |
clinical trial | medical devices | monocentric | A2 | Prof. Sebastian Kuehl | Institut Straumann AG |
Universitäres Zentrum für Zahnmedizin Basel – UZB Klinik für Oralchirurgie, Basel |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | 08.10.2025 | |||||
| 2025-D0075 | Evaluation of a software to predict the postoperative component position in total hip arthroplasty (THA): Accuracy of predictions and impact on interoperative placement in a single centre | clinical trial | medical devices | monocentric | A1 | Prof. Dr. Marcel Jakob | crossklinik AG |
crossklinik, Basel |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | 25.09.2025 | |||||
| 2025-D0073 | Procedural Comparative Evaluation of Pulmonary Vein Isolation Using the FARAWAVE Nav PFA Catheter Without Pre-Ablation Computer Tomography (CT) vs. Conventional Farapulse With Pre-Ablation CT: A singl More ... | clinical trial | medical devices | monocentric | A1 | Dr. Med. Marco Bergonti | Istituto Cardiocentro Ticino - Ente Ospedaliero Cantonale |
Istituto Cardiocentro Ticino - Ente Ospedaliero Cantonale, Lugano |
Comitato etico cantonale Ticino | 17.09.2025 | |||||
| 2025-D0071 | Blink restoration in patients with facial nerve palsy V2 | clinical trial | medical devices | monocentric | C2 | Dr. med. Anthia Papazoglou | Augenklinik Kantonsspital Aarau |
Augenklinik Kantonsspital Aarau, Aarau |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | 14.10.2025 | |||||
| 2025-D0069 |
Role of Slow Waves in the Progression of Neurodegeneration in Isolated REM Sleep Behavior Disorder |
clinical trial | medical devices | monocentric | C2 | Prof. Dr. med. Andreas Luft | University of Zurich |
University Hospital Zurich, Department of Neurology, Zurich |
Kantonale Ethikkommission Zürich | 02.12.2025 | |||||
| 2025-D0068 | DESTINY-Endometrial01: An Open-Label, Sponsor-Blinded, Randomized, Controlled, Multicenter, Phase III Study of Trastuzumab Deruxtecan (T-DXd) Plus Rilvegostomig or Pembrolizumab vs Chemotherapy Plus P More ... | clinical trial | in vitro diagnostic medical devices CDx | multicentric | C2 | Dr. med. Marcus Vetter | AstraZeneca AB |
Kantonsspital Baselland, Liestal HOCH Health Ostschweiz, Kantonsspital St. Gallen Rorschacher Strasse 95 Universitätsspital Zürich, Frauenklinikstrasse 10 |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | Ethikkommission Ostschweiz (EKOS), Kantonale Ethikkommission Zürich | 29.10.2025 | ||||
| 2025-D0067 | A Multi-center, Randomized-controlled, 12-month, split-mouth, Non-inferiority Clinical Trial to Compare the Safety and Performance of two different Curing Modes in the Direct Filling Therapy with a Fl More ... | clinical trial | medical devices | multicentric | C1 | Prof. Dr. med. dent. Klaus Neuhaus | Ivoclar Vivadent AG |
N|DENT ZAHNARZTPRAXIS, Herzogenbuchsee Zahnarztpraxis Chrüzhof, Kreuzstrasse 3b |
Kantonale Ethikkommission Bern | Ethikkommission Nordwest- und Zentralschweiz EKNZ | 23.10.2025 | yes | |||
| 2025-D0065 | OBPM_HARMONY: Physiological data recording over 24 hours using the continual optical Hilo Blood Pressure monitor and an Ambulatory Blood Pressure Monitor: a single-center, prospective clinical study. | clinical trial | medical devices | monocentric | A1 | Pr Grégoire WUERZNER | Aktiia SA |
CHUV, Lausanne |
Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD) | 03.11.2025 | |||||
| 2025-D0063 | Artiqo_RSA: Migration of the cemented A2® Type B prosthesis: a radio stereometric analysis | clinical trial | medical devices | monocentric | A1 | Prof. Karl Stoffel | Universitätsspital Basel |
Universitätsspital Basel, Basel |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | 05.11.2025 | |||||
| 2025-D0060 | Feasibility of unsupervised therapy after neurological or orthopaedical injury in the home setting with a hand rehabilitation device (ReHandyBot) and an assistive smartphone application (RehabCoach): More ... | clinical trial | medical devices | monocentric | C2 | Dr. Bertrand Léger | Rehabilitation Engineering Lab, ETH Zurich |
SUVA clinics, Bellikon |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | 03.10.2025 | |||||
| 2025-D0059 |
20230222 - Measurement of Samples with Tina-quant Lp(a) RxDx to Identify Participants with Elevated Lipoprotein(a) for Prevention of First Major Cardiovascular Events and A Double-blind, Random More ... |
clinical trial | in vitro diagnostic medical devices CDx | multicentric | C2 | PD Dr. med. Stefan Bilz | AMGEN |
HOCH Health Ostschweiz Kantonsspital St.Gallen Klinik für Endokrinologie, Diabetologie, Osteologie und Stoffwechselerkrankungen, St Gallen Inselspital Universitätsklinik für Kardiologie, Bern Luzern More ... |
Ethikkommission Ostschweiz (EKOS) | Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD), Kantonale Ethikkommission Bern, Kantonale Ethikkommission Zürich, Ethikkommission Nordwest- und Zentralschweiz EKNZ, Com More ... | 17.07.2025 | ||||
| 2025-D0058 | The Susatu PHOENIX Trial ‘SPOT’ - A prospective, single-center, interventional trial to determine the clinical performance of a novel osteosynthesis material detector in comparison to standard clinica More ... | clinical trial | medical devices | monocentric | C2 | PD Dr. med. Michael Schär | susatu GmbH |
Inselspital Bern, Bern |
Kantonale Ethikkommission Bern | 10.11.2025 | |||||
| 2025-D0056 | Early feasibility evaluation of the UniBE hybrid closed-loop insulin delivery system in Type 1 Diabetes: UBLoop - Genesis | clinical trial | medical devices | monocentric | C2 | Prof. Dr. med. Markus Laimer | University of Bern |
Universitätsklinik für Diabetologie, Endokrinologie, Ernährungsmedizin & Metabolismus (UDEM), Inselspital, Universitätsspital, CH-3010 Bern |
Kantonale Ethikkommission Bern | 10.11.2025 | |||||
| 2025-D0055 | Prospective evaluation of the Laryngeal Mask Singularity® in adult patients with or without neuromuscular blockade under clinical conditions | clinical trial | medical devices | monocentric | A1 | Prof. Dr. Alexander Dullenkopf | Spital Thurgau Frauenfeld |
Spital Thurgau Frauenfeld, Frauenfeld |
Ethikkommission Ostschweiz (EKOS) | 12.06.2025 | |||||
| 2025-D0054 | Exploration of the functional effect of different hearing aid noise reduction algorithms in an ecologically valid conversational situation | clinical trial | medical devices | monocentric | A1 | Josephine Hollenbach | Sonova AG |
Sonova AG, Stäfa |
Kantonale Ethikkommission Zürich | 05.09.2025 | Study has ended | ||||
| 2025-D0053 | An international, multi-centre observational study to evaluate safety, performance, and clinical benefit of the BeFlow Iliac Covered Stent System | clinical trial | medical devices | monocentric | A1 | Dr Med Maria Antonella Ruffino, MD, EBIR | Bentley InnoMed GmbH |
Ente Ospedaliero Cantonale, Lugano |
Comitato etico cantonale Ticino | 01.10.2025 | |||||
| 2025-D0052 | Certified Comprehensive Eye-Movement Examination in Children with Attention Deficit Hyperactivity Disorder: An Objective, Reproducible and Quantitative Diagnosis in 15 Minutes? | clinical trial | medical devices | multicentric | A1 | Dr. med. Dr. sc. nat. Christine Schneider | Onovis Augenpraxis |
Kinderarztpraxis ADHS Diagnostik und Therapie bei Kindern und Jugendlichen, Bern Onovis Augenpraxis, Bern |
Kantonale Ethikkommission Bern | Kantonale Ethikkommission Bern | 03.09.2025 | yes | |||
| 2025-D0051 | MR45625: A PHASE IIIb, MULTICENTER, SINGLE-ARM STUDY ASSESSING THE EFFECTIVENESS, SAFETY AND PATIENT REPORTED OUTCOMES OF A 36-WEEK REFILL EXCHANGE REGIMEN FOR THE PORT DELIVERY SYSTEM WITH RANIBIZUMA More ... | clinical trial | combination drugs/devices | multicentric | C2 | Prof. Dr. med. Justus Garweg | F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4058 Basel |
Berner Augenklinik, Bern Pallas Kliniken Olten, Louis Giroud-Strasse 20/26 HOCH Health Ostschweiz, Kantonsspital St. Gallen Augenklinik Rorschacher |
Kantonale Ethikkommission Bern | Ethikkommission Ostschweiz (EKOS), Ethikkommission Nordwest- und Zentralschweiz EKNZ | 19.09.2025 | ||||
| 2025-D0050 | Prospective study to evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) to increase the survival of autologous fat transfer for breast reconstruction after radiotherapy. A randomized contr More ... | clinical trial | medical devices | monocentric | A1 | Dr. André-Lévigne Dominik | Service de chirurgie plastique, reconstructive et esthétique, Hôpitaux Universitaires de Genève |
Service de chirurgie plastique, reconstructive et esthétique, Hôpitaux Universitaires de Genève, Genève |
Commission Cantonale d'éthique de la recherche Genève (CCER) | 01.10.2025 | |||||