| BASEC ID | Project title | Type of project | Type of clinical trial | Study phase (clinical trials only) | multi- / monocentric | Category | Principal investigator | Sponsor | Investigational sites | Lead EC | Local EC(s) | Approval date | Minors | Study Ended | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-D0049 | “ASCEND CSP” A Stylet-Driven ICD Lead Intended for Conduction System Pacing IDE Study | clinical trial | medical devices | monocentric | C2 | Professor Dr. med. Haran Burri | Abbott Medical (represented in EU by St. Jude Medical Coordination Center BV |
Hôpitaux Universitaires de Genève (HUG), Genève |
Commission Cantonale d'éthique de la recherche Genève (CCER) | 26.11.2025 | |||||
| 2025-D0048 | A Single-Center, First-in-Human, Randomized, Controlled, Feasibility Study of a New Device for the Real-Time Continuous Monitoring of the Injection Pressure of Local Anesthetic in Subjects Undergoing More ... | clinical trial | medical devices | monocentric | C2 | Dr. med. Roberto Dossi | Service of Anesthesia, Ospedale Regionale di Bellinzona e Valli, EOC |
Ospedale Regionale di Bellinzona e Valli, EOC, Bellinzona |
Comitato etico cantonale Ticino | 27.08.2025 | |||||
| 2025-D0047 | An open-label, multi-national, multi-centre, randomised, single-period parallel study to assess the efficacy, safety and utility of fully closed-loop insulin delivery compared to standard insulin ther More ... | clinical trial | medical devices | monocentric | A1 | Prof. Dr. med. et phil. Lia Bally | Inselspital |
Inselspital, Universitätsspital Bern Universitätsklinik für Diabetologie, Endokrinologie, Ernährungsmedizin und Me-tabolismus UDEM, 3010 Bern |
Kantonale Ethikkommission Bern | 18.06.2025 | |||||
| 2025-D0045 | Neurorehabilitation of cognitive deficits in multiple sclerosis using an adaptive cognitive exergame: randomized, controlled, multi-center clinical trial | clinical trial | medical devices | monocentric | C2 | Prof. Arseny Sokolov | CHUV |
CHUV, Lausanne |
Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD) | 02.09.2025 | |||||
| 2025-D0044 | Clinical evaluation of polymer-infiltrated ceramic network (PICN) material versus zirconia lithium silicate (ZLS) ceramic for the restoration of worn posterior dentitions – A randomized controlled spl More ... | clinical trial | medical devices | monocentric | A1 | PD Dr. med. dent. Pune Nina Paqué | Center of Dental Medicine |
Center of Dental Medicine, Zürich |
Kantonale Ethikkommission Zürich | 17.10.2025 | |||||
| 2025-D0040 | Prospective-randomized trial to demonstrate superiority of SuperCable vs. conventional steel wire for closure after a median sternotomy | clinical trial | medical devices | monocentric | A2 | PD Dr. med. Héctor Rodríguez Cetina Biefer | University Hospital Zürich |
USZ, Zurich |
Kantonale Ethikkommission Zürich | 19.08.2025 | |||||
| 2025-D0039 | BIOresorbable scaffold combined with drug-coated balloons for HYBRID percutaneous coronary intervention versus a conventional drug-eluting stent-based strategy in patients with long and diffuse corona More ... | clinical trial | medical devices | multicentric | A2 | Prof. Dr med. Gregor Leibundgut | Hôpitaux Universitaires de Genève |
Universitätsspital Basel, Klinik für Kardiologie, Basel Hôpitaux Universitaires de Genève, Service de Cardiologie Interventionnelle Rue Gabr |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | Commission Cantonale d'éthique de la recherche Genève (CCER) | 30.07.2025 | ||||
| 2025-D0038 | Monocentric prospective, randomized, non-blinded, active-controlled trial to evaluate the non-inferiority of functional magnetic stimulation (FMS) using the Tesla Chair compared to physiotherapy in More ... | clinical trial | medical devices | monocentric | A1 | Dr. med. Peter Kleimann | Kantonsspital Winterthur |
Frauenklinik Kantonsspital Winterthur, Winterthur |
Kantonale Ethikkommission Zürich | 26.09.2025 | |||||
| 2025-D0037 | A European Multi-Center, Prospective, Single-Arm, Observational Study to Evaluate Real-World Outcomes for the Ion Endoluminal System | clinical trial | medical devices | monocentric | A1 | PD Dr. Thomas Gaisl | Intuitive Surgical, Inc. |
Universitätsspital Zürich, Klinik für Pneumologie, Zürich |
Kantonale Ethikkommission Zürich | 19.08.2025 | |||||
| 2025-D0035 | WO45654 - A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Inavolisib Plus a CDK4/6 Inhibitor and Letrozole Versus Placebo Plus a CDK4 More ... | clinical trial | in vitro diagnostic medical devices CDx | multicentric | C1 | Prof. Dr. Christian Kurzeder | Roche Pharma (Schweiz) AG |
Universitätsspital Basel, Basel Kantonsspital Baden, KSB, Im Ergel 1 Luzerner Kantonsspital, Spitalstrasse Centre hospitalier universitaire vaudois; CHUV, Département d'oncologie Rue de Bugnon 46 |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD), Ethikkommission Nordwest- und Zentralschweiz EKNZ | 02.07.2025 | ||||
| 2025-D0034 | Robotic minimAlly invasive Ventral HErNia repair with Dexter® | clinical trial | medical devices | multicentric | A1 | Dr. Med. Nico Seeger | Distalmotion SA |
Kantonsspital Winterthur, Winterthur Viscera Bauchmedizin Bern, Bern Hirslanden Klinik, Witellikerstrasse 40 |
Kantonale Ethikkommission Zürich | Kantonale Ethikkommission Bern, Kantonale Ethikkommission Zürich | 06.06.2025 | ||||
| 2025-D0032 | Surgical Bioprosthesis Aortic Valve Replacement Vs. Myval Balloon-Expandable THV Series in Patients Aged 65 to 75 with Symptomatic Severe Aortic Stenosis | clinical trial | medical devices | monocentric | A1 | Dr. David Meier | Center for European Research Initiatives in Cardiovascular Medicine (CERIC) |
Centre hospitalier universitaire vaudois (CHUV), Lausanne |
Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD) | 08.09.2025 | |||||
| 2025-D0031 | ARTIDIS Nanomechanical Generated Measurements for Early Breast Lesions | clinical trial | in vitro diagnostic medical devices IVD-MD | monocentric | A2 | Dr, Roberto Rodriguez | ARTIDIS AG |
St Claraspital AG, Basel |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | 23.07.2025 | |||||
| 2025-D0028 | Selective Pulmonary-artery Intervention to Reduce Acute Right-heart tEnsion-II. The SPIRARE II Study | clinical trial | medical devices | monocentric | C2 | Prof. Felix Mahfoud | Jupiter Endovascular Inc. |
Department of Cardiology, University Heart Center Basel, University Hospital Basel, Basel |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | 20.05.2025 | |||||
| 2025-D0027 | Clinical Performance Study Protocol for Use of the VENTANA PD-L1 (SP263) CDx Assay: Evaluation of PD-L1 Expression Levels in Non-small Cell Lung Cancer Specimens from Phase III Study D702GC00001 (ARTE More ... | clinical trial | in vitro diagnostic medical devices CDx | monocentric | C1 | Dr. Karim Abdelhamid | Ventana Medical Systems, Inc. (Roche Tissue Diagnostics or “RTD”) |
CHUV Centre hospitalier universitaire vaudois, Lausanne |
Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD) | 28.08.2025 | |||||
| 2025-D0026 | Post-market clinical follow-up investigation to evaluate safety and effectiveness of Magic InBra™ breast pump in expressing and collecting milk from lactating women`s breast | clinical trial | medical devices | multicentric | A1 | Carola Eichmann | Medela AG |
Medela AG, Baar GIM Suisse AG, General-Wille-Strasse 10 |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | Kantonale Ethikkommission Zürich | 29.04.2025 | ||||
| 2025-D0025 | Comparison of 16F versus 24F chest drain after minimally invasive pulmonary lobectomy and/or segmentectomy: a monocentre prospective randomized controlled trial. | clinical trial | medical devices | monocentric | A1 | Dr. med. Makhmudbek Mallaev | University Hospital Basel |
University Hospital Basel, Basel |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | 16.04.2025 | |||||
| 2025-D0023 |
EARLY Antibiotics aDaptation in ventilator-Acquired-Pneumonia Treatment after Implementation of a Broad-Panel Respiratory Multiplex PCR test: A Multicenter Randomized Control Trial Conducted In Swiss More ... |
clinical trial | in vitro diagnostic medical devices IVD-MD | multicentric | A1 | Dr. Christophe Le Terrier | University Hospitals of Geneva |
Hôpitaux universitaire de Genève, Genève Hôpital cantonal du Tessin, Division of Intensive care CHUV, Dept. of Intensive Care Medicine BH-08-619 CHUV Hôpitaux du Valais, Avenue du Grand-Champsec 80 More ... |
Commission Cantonale d'éthique de la recherche Genève (CCER) | Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD), Comitato etico cantonale Ticino | 05.08.2025 | ||||
| 2025-D0022 |
Retrospective clinical study to investigate the longevity of long-term single tooth restorations from IPS e.max CAD and Press |
clinical trial | medical devices | monocentric | A1 | Dr. med. dent. Lukas Enggist | Ivoclar Vivadent AG |
Ivoclar Vivadent AG, Schaan |
Kantonale Ethikkommission Zürich | 20.05.2025 | |||||
| 2025-D0021 | Clinical Performance Study Protocol for Use of the VENTANA PD-L1 (SP263) CDx Assay: Evaluation of PD-L1 Expression Levels in Non-small Cell Lung Cancer Specimens from Phase III Study CA2241093 (Relati More ... | clinical trial | in vitro diagnostic medical devices CDx | multicentric | C2 | Dr Andreas Schmitt | Bristol-Myers Squibb Company |
University Hospital Basel, Basel Spital Thurgau, Kantonsspital Munsterlingen Spitalcampus 1 Ospedale Cantonale Bellinzona, Viale Officina 3 CHUV, Departement d'oncologie UNIL, Rue due Bugnon 46 |
Ethikkommission Nordwest- und Zentralschweiz EKNZ | Commission cantonale d'Éthique de la Recherche sur l'être humain Vaud (CER-VD), Ethikkommission Ostschweiz (EKOS), Comitato etico cantonale Ticino | 02.07.2025 | ||||